Clinical implications of PON1 (rs662) and TNF-? (rs1799964) genes polymorphism in patients with coronary artery disease

Abstract Background Coronary artery disease (CAD) is the most common kind of heart problem, currently became one leading causes death worldwide and predicted to persist so for next 20 years. The global risk factors CAD include atherosclerosis, genetic predisposition, environment lifestyle. This study aimed find out genotypic association PON1 (rs662) TNF-? (rs1799964) genes with among North Indian populations. A total 330 subjects including 175 cases 155 healthy controls were enrolled in this study. Single nucleotide polymorphism s analyzed by polymerase chain reaction restriction fragment length (PCR–RFLP) method. ?2 Student's t-tests applied comparison alleles genotype frequencies controls. Logistic regression analysis was calculate 95% confidence intervals odds ratios (OR) assessing disease. Results gene QQ, QR, RR genotypes 36.57%, 50.29%, 13.14% 60%, 38.71%, 1.29% controls, respectively. OR 0.38, 1.6, 11.57 ( P < 0.001, = 0.035, 0.001). CC, CT, TT 4.57%, 45.14% 3.23%, 46.45%, 50.32%, 1.437, 1.166, 0.812 0.531, 0.487, 0.347). We found significant difference allele between control, while no observed control. Conclusions polymorphisms significantly associated an elevated CAD, CAD.